Nitroglycerin Induces Late Preconditioning Against Myocardial Infarction in Conscious Rabbits
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Despite Development of Nitrate Tolerance Nitroglycerin Induces Late Preconditioning Against Myocardial Infarction in Conscious Rabbits Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2001 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/hc3201.092218 2001;104:694-699 Circulation. http://circ.ahajournals.org/content/104/6/694 Wide Web at: The online version of this article, along with updated information and services, is located on the World
منابع مشابه
Nitroglycerin induces late preconditioning against myocardial infarction in conscious rabbits despite development of nitrate tolerance.
BACKGROUND Recent studies suggest that the late phase of ischemic preconditioning (PC) can be mimicked by pretreatment with NO donors. The ability of clinically relevant NO donors to induce PC against infarction, however, has not been evaluated. Furthermore, it is unknown whether tolerance to the hemodynamic actions of nitrates also extends to their PC effects. METHODS AND RESULTS Conscious r...
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Kodani, Eitaro, Yu-Ting Xuan, Ken Shinmura, Hitoshi Takano, Xian-Liang Tang, and Roberto Bolli. -Opioid receptor-induced late preconditioning is mediated by cyclooxygenase-2 in conscious rabbits. Am J Physiol Heart Circ Physiol 283: H1943–H1957, 2002. First published July 26, 2002; 10.1152/ajpheart.00150.2002.—Although activation of -opioid receptors is known to induce both early and late preco...
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Nicorandil has been shown to induce an infarct-limiting effect similar to that induced by the early phase of ischemic preconditioning (PC). The goals of this study were to determine whether nicorandil induces a delayed cardioprotection that is analogous to the late phase of ischemic PC and, if so, whether nicorandil-induced late PC is associated with upregulation of cardioprotective proteins. C...
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Although activation of delta-opioid receptors is known to induce both early and late preconditioning (PC) against myocardial infarction, the mechanisms for this salubrious effect are unclear. Furthermore, it is unknown whether delta-opioid receptors can also induce late PC against myocardial stunning. By using conscious rabbits (n = 120) in this study, we found that the delta-opioid receptor ag...
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The goal of this study was to test the hypothesis that the cardioprotective effects of the late phase of ischemic preconditioning (PC) can be mimicked by treatment with NO donors. In phase I (studies of myocardial stunning), conscious rabbits underwent a sequence of six 4-minute coronary occlusion/4-minute reperfusion cycles for 3 consecutive days (days 1, 2, and 3). In group I (controls, n=6),...
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تاریخ انتشار 2001